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ARA vial.png

ARA-290 10mg

$60.00
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ARA 290 is a non-erythropoietic peptide derived from the structure of erythropoietin (EPO), designed to selectively target the innate repair receptor (IRR), a heteromeric complex of the erythropoietin receptor (EPOR) and the β-common receptor (CD131). ARA 290 activates this receptor without stimulating erythropoiesis, distinguishing it from native EPO. Upon binding, it initiates intracellular signaling pathways associated with anti-inflammatory and tissue-protective responses. Structurally, ARA 290 is an 11-amino acid peptide engineered to retain the tertiary configuration necessary for IRR binding while minimizing interaction with the classical EPOR homodimer responsible for red blood cell production.

Research applications include investigating inflammatory cytokine inhibition, particularly IL-6 and IL-12, along with modulation of macrophage-mediated immune responses and interactions with TRPV1 channels related to neuropathic pain and small nerve fiber function.

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ARA 290 is a non-erythropoietic peptide derived from the structure of erythropoietin (EPO), designed to selectively target the innate repair receptor (IRR), a heteromeric complex of the erythropoietin receptor (EPOR) and the β-common receptor (CD131). ARA 290 activates this receptor without stimulating erythropoiesis, distinguishing it from native EPO. Upon binding, it initiates intracellular signaling pathways associated with anti-inflammatory and tissue-protective responses. Structurally, ARA 290 is an 11-amino acid peptide engineered to retain the tertiary configuration necessary for IRR binding while minimizing interaction with the classical EPOR homodimer responsible for red blood cell production.

Research applications include investigating inflammatory cytokine inhibition, particularly IL-6 and IL-12, along with modulation of macrophage-mediated immune responses and interactions with TRPV1 channels related to neuropathic pain and small nerve fiber function.

Purity: >99%

Supplied as: Solid

Solubility: Water-soluble

Storage (lyophilized): stable at 4C for ≤ 2 years. Stable at -18C for ≤ 3 years.

*Note: lyophilized peptides can remain stable at room temperature for 30-60 days, but should be stored at 4C for optimum stability and longevity.

Storage (reconstituted): stable at 4C for ≤ 30 days. Long term storage in aqueous solution not recommended without sterile buffer at pH 5-6 and freezing to -80C.

WARNING: This product is NOT for human consumption or use in veterinary applications. Research use only.

Batch Specific Data
Laboratory Name Size Batch # Key Date Purity (%) Mass (mg)
Janoshik Analytical 10mg 58747 WTKX8G997E66 03/03/25 99.930 9.74